Let's talk immunity with experts

Let’s get the expert view on immunity from Prof. dr. Joost van Neerven, Professor of Mucosal Immunity and member of Cell Biology and Immunology Group at Wageningen University & Research in the Netherlands. Today, he explains the role of specific nutrients when it comes to building immunity in early life.
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Explaining the immunoregulatory benefits of lipids

Explaining the immunoregulatory benefits of lipids

The term ‘lipids’ covers both short-chain fatty acids (SCFAs), which are produced by gut microbiota, and long-chain polyunsaturated fatty acids (LCPUFAs) such as DHA and ARA, a type of resp. omega-3 and omega-6. Both types of fatty acid have been scientifically demonstrated to offer a variety of health benefits for infants, including when it comes to immunity.[19-23]

We asked Prof. dr. Joost van Neerven to tell us more about how lipids influence the immune response. He explains how SCFAs are known to support the barrier function of protective epithelial cells, and to inhibit inflammation. Omega-3s and -6s like DHA and ARA also have an anti-inflammatory effect, which is one of the reasons why they are such an important component of breast milk.

Preserving the goodness of bovine derived immunoglobulins

Preserving the goodness of bovine derived immunoglobulins

We often talk about how amazing the human immune system is, but when was the last time you had a conversation about mucous membranes? These guard the body at every potential site of infection, enabling immunoglobulins, otherwise known as antibodies, to get to work protecting our respiratory and digestive systems by binding to pathogens.

Prof. dr. Joost van Neerven tells us how the mucosal immune system protects the body in early life, shedding more light on the role of immunoglobulins that are present in breast milk. Researchers are now exploring the potential benefits of bovine derived immunoglobulins, present in cow’s milk, and how they respond to human pathogens. Watch as he explains why it’s important to preserve the nutritional content and functional abilities of bovine derived immunoglobulins through gentler processing methods.

Infant immunity and the gut microbiota

Infant immunity and the gut microbiota

Even before they are born, every person is the host to colonies of bacteria in and on their bodies, mostly in the gut. Together, these bacteria form the human microbiota. Did you know that the composition of an infant’s gut microbiota can influence the way their immune system develops and behaves?

In this video, Prof. dr. Joost van Neerven explains how breast milk plays a role in establishing an infant’s gut microbiota. It contains many beneficial nutrients, including complex sugars called oligosaccharides, which nourish certain strains of “good” bacteria that can support the immune system. Watch the video for his expert explanation of how oligosaccharides can influence microbiota, and how – in turn – the microbiota can influence the immune system.

Related Ingredients

 

Aequival® 2’-FL

Can support immunity by stimulating the growth of Bifidobacteria1,2, reducing the risk of infections3-6, and via its potential anti-inflammatory effect8,9 and role in gut maturation7.

 

 

Vivinal® MFGM

Supports the development of the immune system via its potential role in gut maturation11,12,14, gut barrier function10,13 and by reducing the risk of infections15-18

 

 

Vana-Sana ® Micro-encapsulated LC-PUFA oils

Features DHA and ARA, involved in the prevention of common respiratory complaints and diarrhoea20,21. These fatty acids steer cells of the adaptive immune system22 and assist in gut barrier integrity23

 

 

About Prof. Dr. Joost van Neerven

Prof. dr. Joost van Neerven is a senior Scientist at FrieslandCampina and Professor of Mucosal Immunity at Wageningen University, the Netherlands. Trained as a biologist, he received his PhD in 1995 from the University of Amsterdam, the Netherlands on the role of T cells in allergy. He headed the immunology lab ALK-Abello in Denmark and studied the application of allergens for immunotherapy and the underlying immunological mechanisms. In 2003, he co-founded Bioceros BV, a biotechnology company that develops and manufactures therapeutic monoclonal antibodies.

References

  1. Yu, Z. T. et al. The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota. Glycobiology 23, 169–177 (2013).
  2. Lewis, Z. T. et al. Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants. Microbiome 3, 13 (2015).
  3. Weichert, S. et al. Bioengineered 2’-fucosyllactose and 3-fucosyllactose inhibit the adhesion of Pseudomonas aeruginosa and enteric pathogens to human intestinal and respiratory cell lines. Res. 33, 831–8 (2013).
  4. Morrow, A. L. et al. Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants. Pediatr. 145, 297–303 (2004).
  5. Puccio, G. et al. Effects of Infant Formula with Human Milk Oligosaccharides on Growth and Morbidity: A Randomized Multicenter Trial. JPGN 64, 624–631 (2017).
  6. Reverri, E., Devitt, A., Kajzer, J., Baggs, G. & Borschel, M. Review of the Clinical Experiences of Feeding Infants Formula Containing the Human Milk Oligosaccharide 2′-Fucosyllactose. Nutrients 10, 1346 (2018).
  7. Holscher, H. D., Davis, S. R. & Tappenden, K. A. Human milk oligosaccharides influence maturation of human intestinal Caco-2Bbe and HT-29 cell lines. J. Nutr. 144, 586–91 (2014).
  8. Autran, C. A., Schoterman, M. H. C., Jantscher-Krenn, E., Kamerling, J. P. & Bode, L. Sialylated galacto-oligosaccharides and 2’-fucosyllactose reduce necrotising enterocolitis in neonatal rats.  J. Nutr. 116, 294–299 (2016).
  9. Goehring, K. C. et al. Similar to Those Who Are Breastfed , Infants Fed a Formula Containing 2’-Fucosyllactose Have Lower Inflammatory Cytokines in a Randomized. J Nutr 146, 2559–2566 (2016).
  10. Anderson RC, MacGibbon AKH, Haggarty N, et al (2018) Bovine dairy complex lipids improve in vitro measures of small intestinal epithelial barrier integrity. PLoS One. 2018 Jan 5;13(1):e0190839.
  11. Motouri M, Matsuyama H, Yamamura J, et al (2003) Milk sphingomyelin accelerates enzymatic and morphological maturation of the intestine in artificially reared rats. J Pediatr Gastroenterol Nutr. 2003 Feb;36(2):241-7
  12. Lee H, Zavaleta N, Chen S-Y, et al (2018) Effect of bovine milk fat globule membranes as a complementary food on the serum metabolome and immune markers of 6-11-month-old Peruvian infants. npj Sci Food 2:6.
  13. Snow DR, Ward RE, Olsen a, et al (2011) Membrane-rich milk fat diet provides protection against gastrointestinal leakiness in mice treated with lipopolysaccharide. J Dairy Sci 94:2201–2212.
  14. Bhinder G, Allaire JM, Garcia C, et al (2017) Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development. Sci Rep 7:45274.
  15. Zavaleta, N. et al. Efficacy of an MFGM-enriched complementary food in diarrhea, anemia, and micronutrient status in infants. J. Pediatr. Gastroenterol. Nutr. 53, 561–568 (2011).
  16. Timby, N. et al. Infections in infants fed formula supplemented with bovine milk fat globule membranes. J. Pediatr. Gastroenterol. Nutr. 60, 384–389 (2015).
  17. Li F, Wu SS, Berseth CL, et al (2019) Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial. J Pediatr 215:24-31.e8.
  18. Veereman-Wauters, G. et al. Milk fat globule membrane (INPULSE) enriched formula milk decreases febrile episodes and may improve behavioral regulation in young children. Nutrition 28, 749–752 (2012).
  19. Field CJ, Van Aerde JE, Robinson LE, Clandinin MT. (2008) Effect of providing a formula supplemented with long-chain polyunsaturated fatty acids on immunity in full-term neonates. Br J Nutr. 2008 Jan;99(1):91-9.
  20. Lapillone A. Enteral and Parenteral Lipid Requirements of Preterm Infants. In: Koletzko B, Poindexter B, Uauy R, editors. Nutr. Care Preterm Infants Sci. Basis Pract. Guidel., Basel: Karger; 2014, p. 82–98. doi:10.1159/000358460.
  21. Birch EE, Khoury JC, Berseth CL, Castañeda YS, Couch JM, Bean J, et al. The Impact of Early Nutrition on Incidence of Allergic Manifestations and Common Respiratory Illnesses in Children. J Pediatr 2010;156:902-906.e1. doi:10.1016/j.jpeds.2010.01.002.
  22. Field CJ, Van Aerde JE, Robinson LE, Thomas Clandinin M. Effect of providing a formula supplemented with long-chain polyunsaturated fatty acids on immunity in full-term neonates. Br J Nutr 2008;99:91–9. doi:10.1017/S0007114507791845.
  23. Radzikowska U, Rinaldi AO, Çelebi Sözener Z, et al (2019) The Influence of Dietary Fatty Acids on Immune Responses. Nutrients. 2019 Dec 6;11(12):2990.