Ingredient Index

Lactoferrin

Lactoferrin is a natural, iron-binding milk glycoprotein that is present in high concentrations in human milk ⁹⁴Manzoni, P., Dall’Agnola, A., Tomé, D., Kaufman, D. A., Tavella, E., Pieretto, M., Messina, A., De Luca, D., Bellaiche, M., Mosca, A., Piloquet, H., Simeoni, U., Picaud, J. C., & Del Vecchio, A. (2018). Role of Lactoferrin in Neonates and Infants: An Update. American Journal of Perinatology, 35(6), 561–565. https://doi.org/10.1055/s-0038-1639359 ¹⁶⁷Yang, Z., Jiang, R., Chen, Q., Wang, J., Duan, Y., Pang, X., Jiang, S., Bi, Y., Zhang, H., Lönnerdal, B., Lai, J., & Yin, S. (2018). Concentration of lactoferrin in human milk and its variation during lactation in different Chinese populations. Nutrients, 10(9), 1–10. https://doi.org/10.3390/nu10091235 and can also be isolated from bovine milk. Lactoferrin has been shown to support the immune system ²⁸Drago-Serrano, M., Campos-Rodríguez, R., Carrero, J., & de la Garza, M. (2017). Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections. International Journal of Molecular Sciences, 18(3), 501. https://doi.org/10.3390/ijms18030501 ⁷⁸Kell, D. B., Heyden, E. L., & Pretorius, E. (2020). The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria. Frontiers in Immunology, 11, 1221. https://doi.org/10.3390/molecules20069703. Studies in infants suggest it can reduce the risk of respiratory and gastrointestinal infections ²²Chen, K., Chai, L., Li, H., Zhang, Y., Xie, H. M., Shang, J., Tian, W., Yang, P., & Jiang, A. C. (2016). Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial. Nutrition, 32(2), 222–227. https://doi.org/10.1016/j.nut.2015.08.010 ⁸⁰King, J. C., Cummings, G. E., Guo, N., Trivedi, L., Readmond, B. X., Keane, V., Feigelman, S., & De Waard, R. (2007). A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants. Journal of Pediatric Gastroenterology and Nutrition, 44(2), 245–251. https://doi.org/10.1097/01.mpg.0000243435.54958.68 ³⁵Li, F., Wu, S. S., Berseth, C. L., Harris, C. L., Richards, J. D., Wampler, J. L., Zhuang, W., Cleghorn, G., Rudolph, C. D., Liu, B., Shaddy, D. J., & Colombo, J. (2019). Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial. Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2019.08.030.

Vivinal® Lactoferrin

Supports viral and bacterial immune response
Can reduce risk of infections
Shows immunomodulatory effects

Purity level (%)

Ash level (%)

0.5

Moisture (%)

3.5

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What is lactoferrin?

Lactoferrin is a natural, iron-binding glycoprotein that is present in human milk in high concentrations ⁹⁴Manzoni, P., Dall’Agnola, A., Tomé, D., Kaufman, D. A., Tavella, E., Pieretto, M., Messina, A., De Luca, D., Bellaiche, M., Mosca, A., Piloquet, H., Simeoni, U., Picaud, J. C., & Del Vecchio, A. (2018). Role of Lactoferrin in Neonates and Infants: An Update. American Journal of Perinatology, 35(6), 561–565. https://doi.org/10.1055/s-0038-1639359 ¹⁶⁷Yang, Z., Jiang, R., Chen, Q., Wang, J., Duan, Y., Pang, X., Jiang, S., Bi, Y., Zhang, H., Lönnerdal, B., Lai, J., & Yin, S. (2018). Concentration of lactoferrin in human milk and its variation during lactation in different Chinese populations. Nutrients, 10(9), 1–10. https://doi.org/10.3390/nu10091235. It has also been identified in a number of mammalian species, including in cow’s milk. Lactoferrin can be isolated from cow’s milk and can be added to infant and young child formulations.

What are the health benefits of lactoferrin?

Lactoferrin helps to support a normal immune response against viruses and bacteria ²⁷Donovan, S. M. (2016). The Role of Lactoferrin in Gastrointestinal and Immune Development and Function: A Preclinical Perspective. Journal of Pediatrics, 173, S16–S28. https://doi.org/10.1016/j.jpeds.2016.02.072 ³⁴Elzoghby, A. O., Abdelmoneem, M. A., Hassanin, I. A., Abd Elwakil, M. M., Elnaggar, M. A., Mokhtar, S., Fang, J. Y., & Elkhodairy, K. A. (2020). Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand. Biomaterials, 263(August), 120355. https://doi.org/10.1016/j.biomaterials.2020.120355. It can thereby reduce the risk of gastro-intestinal and respiratory tract infection in infants and young children ²²Chen, K., Chai, L., Li, H., Zhang, Y., Xie, H. M., Shang, J., Tian, W., Yang, P., & Jiang, A. C. (2016). Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial. Nutrition, 32(2), 222–227. https://doi.org/10.1016/j.nut.2015.08.010 ⁴⁵Gao, Y., Hou, L., Lu, C., Wang, Q., Pan, B., & Wang, Q. (2020). Enteral Lactoferrin Supplementation for Preventing Sepsis and Necrotizing Enterocolitis in Preterm Infants : A Meta ‑ Analysis With Trial Sequential Analysis of Randomized Controlled Trials. Frontiers in Pharmacology, 11, 1186. https://doi.org/10.3389/fphar.2020.01186 ⁸⁰King, J. C., Cummings, G. E., Guo, N., Trivedi, L., Readmond, B. X., Keane, V., Feigelman, S., & De Waard, R. (2007). A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants. Journal of Pediatric Gastroenterology and Nutrition, 44(2), 245–251. https://doi.org/10.1097/01.mpg.0000243435.54958.68 ³⁵Li, F., Wu, S. S., Berseth, C. L., Harris, C. L., Richards, J. D., Wampler, J. L., Zhuang, W., Cleghorn, G., Rudolph, C. D., Liu, B., Shaddy, D. J., & Colombo, J. (2019). Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial. Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2019.08.030 ¹⁴⁰Tarnow-Mordi, W. O., Abdel-Latif, M. E., Martin, A., Pammi, M., Robledo, K., Manzoni, P., Osborn, D., Lui, K., Keech, A., Hague, W., Ghadge, A., Travadi, J., Brown, R., Darlow, B. A., Liley, H., Pritchard, M., Kochar, A., Isaacs, D., Gordon, A., … Espinoza, D. (2020). The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. The Lancet Child and Adolescent Health, 4(6), 444–454. https://doi.org/10.1016/S2352-4642(20)30093-6. Lactoferrin has also been demonstrated to play an immune-modulatory role ⁸³Kruzel, M. L., Zimecki, M., & Actor, J. K. (2017). Lactoferrin in a context of inflammation-induced pathology. In Frontiers in Immunology (Vol. 8, Issue NOV). Frontiers Media S.A. https://doi.org/10.3389/fimmu.2017.01438.

What are the processing benefits of lactoferrin?

Vivinal® Lactoferrin is produced not from whey but from high-quality fresh milk that we receive daily, directly from FrieslandCampina’s member farmers. Our careful extraction method results in consistent high purity, and our spray-drying process creates a powder with more homogenous and smaller particle size distribution compared to alternatives in the market. Vivinal® Lactoferrin is manufactured under infant-formula grade conditions.

Product substantiation and benefits Vivinal® Lactoferrin

Why choose lactoferrin from FrieslandCampina Ingredients?

We are proud to be market leader with more than 25 years of experience in lactoferrin production. We offer the support of our reliable and robust methods to analyse and quantify the composition of your infant milk formula, ensuring the right balance of lactoferrin and other ingredients. Vivinal® Lactoferrin complies with both Chinese and EU legislation.

Want to know more about the benefits of lactoferrin?

FrieslandCampina Ingredients provides high quality lactoferrin to apply in your infant milk and young child formula products. nourish babies after birth and during childhood. Our innovations are backed by over 75 years’ experience in manufacturing and research in the field of early life nutrition. Get in touch for personalised advice on how to bring the benefits of lactoferrin to your infant milk formula solution.

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Ingredient Index

Lactoferrin

Vivinal® Lactoferrin

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