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New study Sialyllactose and Galactooligosaccharides Promote Epithelial Barrier Functioning

March 21, 2019

An exciting new in vitro study suggests that both GOS (galacto-oligosaccharides) and SL (sialyllactose) can protect and promote gut health and barrier function, which may be of relevance during early life, adulthood (e.g. colitis), as well as in older adults.

FrieslandCampina’s Vivinal® GOS as well as the human milk oligosaccharide SL were shown to directly interact with the cells lining the inside of the intestine, where they can support differentiation. Furthermore, both promoted wound healing in a damaged epithelial cell culture.

In addition, GOS and SL differentially modulated gut microbiota composition and short chain fatty acid production in infant and adult faecal cultures, by promoting the outgrowth of Bifidobacteria and Bacteroides, respectively. Interestingly, SL also promoted growth of Faecalibacterium prausnitzii, Bacteroides fragilis and Bacteroides thetaiotaomicron, which have been associated with reduction of colitis.

Future studies in humans are needed to substantiate these findings.

Read the full research here: https://www.frontiersin.org/articles/10.3389/fimmu.2019.00094/full